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Friday, January 27, 2012

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Paterno's son: 'Dad, you won. You can go home now'

Jay Paterno, son of former Penn State football coach Joe Paterno, speaks during a memorial service for Joe Paterno at Penn State's Bryce Jordan Center in State College, Pa., Thursday, Jan. 26, 2012. A capacity crowd of more than 12,000 packed the Bryce Jordan Center for one more tribute to Paterno, the Hall of Fame football coach who died Sunday from lung cancer. (AP Photo/Gene J. Puskar)

Pallbearers including sons Jay Paterno, foreground right, and Scott Paterno, foreground center, carry the casket with the remains of former Penn State coach Joe Paterno after funeral services at the Pasquerilla Spiritual Center on the Penn State campus Wednesday, Jan. 25, 2012 in State College, Pa. Paterno died Sunday morning, Jan. 22. (AP Photo/Alex Brandon)

Phil Knight adjust the microphones before he speaks during a memorial service for former Penn State football coach Joe Paterno at Penn State's Bryce Jordan Center in State College, Pa. Thursday Jan. 26, 2012. Knight, the Nike founder, got a standing ovation at Paterno's public memorial for defending the late coach's response to an accusation of child sex abuse against a former assistant. (AP Photo/Alex Brandon)

Phil Knight, former CEO and co-founder of Nike, becomes emotional as he speaks during a memorial service for former Penn State football coach Joe Paterno at Penn State's Bryce Jordan Center in State College, Pa. Thursday Jan. 26, 2012. A capacity crowd of more than 12,000 packed the Bryce Jordan Center for one more tribute to Paterno, the Hall of Fame football coach who died Sunday from lung cancer. (AP Photo/Alex Brandon)

Sue Paterno, center, wife of former Penn State football coach Joe Paterno, consoles her grandson as they leave a memorial service for Joe at Penn State's Bryce Jordan Center in State College, Pa., Thursday Jan. 26, 2012. A capacity crowd of more than 12,000 packed the Bryce Jordan Center for one more tribute to Paterno, the Hall of Fame football coach who died Sunday from lung cancer. (AP Photo/Gene J. Puskar)

STATE COLLEGE, Pa. (AP) ? Jay Paterno leaned over his dying father, gave him a kiss, and whispered in his ear.

"Dad, you won," he said. "You did all you could do. You've done enough. We all love you. We won. You can go home now."

Joe Paterno died Sunday of lung cancer at age 85.

At a memorial service Thursday that drew some 12,000 people to the Penn State basketball arena, Jay Paterno reflected on what he called the "magnificent daylight" of his legendary father's life. It was primarily a glowing tribute to Paterno and his accomplishments during 46 years as Penn State's football coach ? but also an opportunity to defend his legacy against criticism that he failed to do more when told about an alleged child sexual assault involving one of his former assistants.

Nike founder and CEO Phil Knight won a thunderous standing ovation when he defended Paterno's handling of the 2002 allegations against former defensive coordinator Jerry Sandusky. Paterno, he hinted, had been made a scapegoat.

"If there is a villain in this tragedy, it lies in that investigation and not in Joe Paterno's response," Knight said. Paterno's widow, Sue, was among those rising to their feet.

Capping three days of mourning on campus, the 2?-hour ceremony was filled with lavish praise for the man called "JoePa." Paterno racked up more wins ? 409 ? than any other major-college football coach, led his team to two national championships, and preached "success with honor" while insisting his athletes focus on academics. The Paternos donated millions to Penn State.

Though the campus and surrounding community have been torn with anger over the Sandusky scandal and Paterno's summary dismissal by the board of trustees two months before his death, Jay Paterno said his father didn't hold a grudge.

"Despite all that had happened to him, he never wavered in his belief, in his dream, of Penn State. He told me he wanted to use his remaining time on earth to see Penn State continue to thrive. He never spoke ill and never wanted anyone to feel badly for him," Paterno said.

Players from each decade of Paterno's career as the Nittany Lions' coach spoke in loving terms about their mentor, saying he rode them hard, but always had their best interests at heart and encouraged them to complete their educations and become productive members of their communities.

Among the speakers were Michael Robinson, who played for Paterno from 2002 to 2005 and flew in from Hawaii, where he was practicing for his first Pro Bowl; star quarterback Todd Blackledge from the 1980s; and Jimmy Cefalo, a star in the 1970s. Like Robinson, Blackledge and Cefalo went on to play in the NFL.

Former NFL player Charles V. Pittman, speaking for players from the 1960s, called Paterno a lifelong influence and inspiration.

Pittman said Paterno challenged his young players, once bringing Pittman to tears in his sophomore year. He said he realized later that the coach was molding him into the man he would become.

"What I now know is that Joe wasn't trying to build perfection. That doesn't exist and he knew it. He was, bit by bit, building a habit of excellence," said Pittman, now a media executive on the board of The Associated Press.

Paterno was fired Nov. 9 after he was criticized for not going to police in 2002 when he was told that Sandusky had been seen sexually assaulting a boy in the showers. Sandusky was arrested in November and is awaiting trial on charges that he molested 10 boys over a 15-year span.

As the scandal erupted, Pennsylvania's state police commissioner said Paterno may have met his legal duty but not his moral one. Penn State president Graham Spanier was also fired in the fallout.

Knight, appearing about midway through the memorial, became the first speaker to explicitly address the scandal. He said the coach "gave full disclosure to his superiors, information that went up the chains to the head of the campus police and the president of the school. The matter was in the hands of a world-class university, and by a president with an outstanding national reputation."

Lanny J. Davis, an attorney for the board, responded after the service by saying: "All the reasons for the board's difficult and anguished decision ? made unanimously, including former football players and everyone who still loves Coach Paterno and his memory ? reached a decision which was heartfelt. All 32."

"The facts speak for themselves" and include the grand jury testimony, he said.

Chris Marrone, another former player who eulogized Paterno, said Knight was his "new hero" for expressing the "pent-up frustration" of Paterno's supporters.

"I think the response that he got is indicative of how folks feel," Marrone said.

Only one member of the university administration ? the dean of the college of liberal arts ? and no one from the board of trustees spoke at the memorial, which was arranged primarily by the Paterno family.

People said it felt good to remember and celebrate the good times.

Tennessee Titans coach Mike Munchak, who played for Paterno, said he attended the service "because I'm a part of his legacy."

"It was not only about football," Munchak said. "It was about life and how he affected all of us as men."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-27-Penn%20State-Paterno/id-369a863f19c3447cae0ce1d19ef2ffb7

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Gingrich, Romney play for cheers in Florida debate (reuters)

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Thursday, January 26, 2012

In State of the Union, Obama Says American Dream in Peril (Time.com)

(WASHINGTON) -- Declaring the American dream under siege, President Barack Obama called Tuesday night for a flurry of help for a hurting middle class and higher taxes on millionaires, delivering a State of the Union address packed with re-election themes. Restoring a fair shot for all, Obama said, is "the defining issue of our time."

Obama outlined a vastly different vision for fixing the country than the one pressed by the Republicans challenging him in Congress and fighting to take his job in the November election. He pleaded for an active government that ensures economic fairness for everyone, just as his opponents demand that the government back off and let the free market rule.

Obama offered steps to help students afford college, a plan for more struggling homeowners to refinance their homes and tax cuts for manufacturers. He threw in politically appealing references to accountability, including warning universities they will lose federal aid if they don't stop tuition from soaring. (More on what the government could do to help housing.)

Standing in front of a divided Congress, with bleak hope this election year for much of his legislative agenda, Obama spoke with voters in mind.

"We can either settle for a country where a shrinking number of people do really well, while a growing number of Americans barely get by," Obama said. "Or we can restore an economy where everyone gets a fair shot, everyone does their fair share, and everyone plays by the same set of rules."

A rare wave of unity splashed over the House chamber at the start. Rep. Gabrielle Giffords, survivor of an assassination attempt one year ago, received sustained applause from her peers and cheers of "Gabby, Gabby, Gabby." She blew a kiss to the podium. Obama embraced her.

Lawmakers leapt to their feet when Obama said near the start of his speech that terrorist leader Osama bin Laden, killed by a raid authorized by the president, will no longer threaten America.

At the core of Obama's address was the improving but deeply wounded economy -- the matter still driving Americans' anxiety and the one likely to determine the next presidency.

"The state of our union is getting stronger," Obama said, calibrating his words as millions remain unemployed. Implicit in his declaration that the American dream is "within our reach" was the recognition that, after three years of an Obama presidency, the country is not there yet. (More on Obama's refinance program.)

He spoke of restoring basic goals: owning a home, earning enough to raise a family, putting a little money away for retirement.

"We can do this," Obama said. "I know we can." He said Americans are convinced that "Washington is broken," but he also said it wasn't too late to cooperate on important matters.

Republicans were not impressed. They applauded infrequently, though they did cheer when the president quoted "Republican Abraham Lincoln" as saying: "That government should do for people only what they cannot do better by themselves -- and no more."

Indiana Gov. Mitch Daniels, offering the formal GOP response, called Obama's policies "pro-poverty" and his tactics divisive.

"No feature of the Obama presidency has been sadder than its constant efforts to divide us, to curry favor with some Americans by castigating others," Daniels said in excerpts released before the address.

In a signature swipe at the nation's growing income gap, Obama called for a new minimum tax rate of at least 30 percent on anyone making over $1 million. Many millionaires -- including one of his chief rivals, Republican Mitt Romney -- pay a rate less than that because they get most of their income from investments, which are taxed at a lower rate.

"Now you can call this class warfare all you want," Obama said, responding to a frequent criticism from the GOP presidential field. "But asking a billionaire to pay at least as much as his secretary in taxes? Most Americans would call that common sense."

Obama calls this the "Buffett rule," named for billionaire Warren Buffett, who has said it's unfair that his secretary pays a higher tax rate than he does. Emphasizing the point, Buffett's secretary, Debbie Bosanek, attended the address in first lady Michelle Obama's box.

Obama underlined every proposal with the idea that hard work and responsibility still count. He was targeting independent voters who helped seal his election in 2008 and the frustrated masses in a nation pessimistic about its course.

In a flag-waving defense of American power and influence abroad, Obama said the U.S. will safeguard its own security "against those who threaten our citizens, our friends and our interests." On Iran, he said that while all options are on the table to prevent Iran from acquiring a nuclear weapon -- an implied threat to use military force -- "a peaceful resolution of this issue is still possible."

With Congress almost universally held in low regard, Obama went after an easy target in calling for reforms to keep legislators from engaging in insider trading and holding them to the same conflict-of-interest standards as those that apply to the executive branch.

With the foreclosure crisis on ongoing sore spot despite a number of administration housing initiatives over the past three years, Obama proposed a new program to allow homeowners with privately held mortgages to refinance at lower interest rates. Administration officials offered few details but estimated savings at $3,000 a year for average borrowers.

Obama proposed steps to crack down on fraud in the financial sector and mortgage industry, with a Financial Crimes Unit to monitor bankers and financial service professionals, and a separate special unit of federal prosecutors and state attorneys general to expand investigations into abusive lending that led to the housing crisis.

At a time of tight federal budgets and heavy national debt, Obama found a ready source of money to finance his ideas: He proposed to devote half of the money no longer being spent on the U.S. military in Iraq and Afghanistan to "do some nation-building right here at home," to help create more jobs and increase competitiveness. The other half, he said, would go to help pay down the national debt.

Obama also offered a defense of regulations that protect the American consumer -- regulations often criticized by Republicans as job-killing obstacles.

"Millions of Americans who work hard and play by the rules every day deserve a government and a financial system that do the same," Obama said. "It's time to apply the same rules from top to bottom: No bailouts, no handouts and no copouts. An America built to last insists on responsibility from everybody."

Obama will follow up Tuesday night's address with a three-day tour of five states key to his re-election bid. On Wednesday he'll visit Iowa and Arizona to promote ideas to boost American manufacturing; on Thursday in Nevada and Colorado he'll discuss energy, and in Michigan on Friday he'll talk about college affordability, education and training.

Polling shows Americans are divided about Obama's overall job performance but unsatisfied with his handling of the economy.

The speech Tuesday night comes just one week before the Florida Republican primary that could help set the trajectory for the rest of the race.

Romney, caught up in a tight contest with a resurgent Newt Gingrich, commented in advance to Obama's speech.

"Tonight will mark another chapter in the misguided policies of the last three years -- and the failed leadership of one man," Romney said from Florida.

PHOTOS: TIME's Pictures of the Week

PHOTOS: Cartoons of the Week

View this article on Time.com

Avastin, Sutent increase breast cancer stem cells

Wednesday, January 25, 2012

Cancer treatments designed to block the growth of blood vessels were found to increase the number of cancer stem cells in breast tumors in mice, suggesting a possible explanation for why these drugs don't lead to longer survival, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.

The drugs Avastin and Sutent have been looked at as potential breast cancer treatments. But while they do shrink tumors and slow the time till the cancer progresses, the effect does not last, and the cancer eventually regrows and spreads.

"This study provides an explanation for the clinical trial results demonstrating that in women with breast cancer antiangiogenic agents such as Avastin delay the time to tumor recurrence but do not affect patient survival. If our results apply to the clinic, it suggests that in order to be effective, these agents will need to be combined with cancer stem cell inhibitors, an approach now being explored in the laboratory," says study author Max S. Wicha, M.D., director of the U-M Comprehensive Cancer Center.

The researchers treated mice with breast cancer using Avastin (bevacizumab) and Sutent (sunitinib), both of which work by stopping the growth and formation of blood vessels, a process called angiogenesis. The researchers found that tumors treated with these drugs developed more cancer stem cells, the small number of cells within a tumor that fuel a cancer's growth and spread and that are often resistant to standard treatment. Both the number of cancer stem cells and the percentage of cancer stem cells that make up the tumor increased after being treated with each of these therapies.

The researchers found that the cancer stem cells increased because of a cellular response to low oxygen, a condition called hypoxia. And they were able to determine the specific pathways involved in hypoxia that activate the cancer stem cells.

Results of the study appear online in the Proceedings of the National Academy of Sciences Early Edition.

The U.S. Food and Drug Administration recently revoked approval of Avastin for treating breast cancer, although the drug is approved for use in other types of cancer. The reversal was in response to clinical trials showing that the drug's benefit was short-lived, with breast cancer patients quickly relapsing and the cancer becoming more invasive and spreading further throughout the body. Overall, the drug did not help patients live any longer.

The current study suggests the possibility of combining anti-angiogenesis drugs with a cancer stem cell inhibitor to enhance the benefit of this treatment. The researchers are testing this approach in mice and preliminary data looks promising.

Breast cancer statistics: 209,060 Americans will be diagnosed with breast cancer this year and 40,230 will die from the disease, according to the American Cancer Society

###

University of Michigan Health System: http://www.med.umich.edu

Thanks to University of Michigan Health System for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 56 time(s).

Source: http://www.labspaces.net/117049/Avastin__Sutent_increase_breast_cancer_stem_cells

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Wednesday, January 25, 2012

Chinese Researchers Lead in Howard Hughes Awards

[unable to retrieve full-text content]China?s government has spent billions in recent years into building a top-notch research establishment. Now comes a hint that the effort is beginning to pay off.

Source: http://feeds.nytimes.com/click.phdo?i=8a82a6da071a97ad05dd0a1687663a5e

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Giffords bids farewell but promises to return

U.S. Rep Gabrielle Giffords, left, tours the Gabrielle Giffords Family Assistance Center, one of her favorite charities, with Community Food Bank CEO Bill Carnegie Monday, Jan. 23, 2012, in Tucson, Ariz. The tour is her last act as a congresswoman in Tucson before her resignation this week. (AP Photo/Matt York, Pool)

U.S. Rep Gabrielle Giffords, D-Ariz., tours the Gabrielle Giffords Family Assistance Center, one of her favorite charities, with her staffer Ron Barber, Monday, Jan. 23, 2012, in Tucson, Ariz. The tour is her last act as a congresswoman in Tucson before her resignation this week. (AP Photo/Matt York, Pool)

U.S. Rep Gabrielle Giffords, D-Ariz., center, tours the Gabrielle Giffords Family Assistance Center, one of her favorite charities, with Community Food Bank CEO Bill Carnegie and food bank board member Fran McNeely, Monday, Jan. 23, 2012, in Tucson, Ariz. The tour is Giffords' last act as a congresswoman in Tucson before her resignation this week. (AP Photo/Matt York, Pool)

U.S. Rep Gabrielle Giffords, D-Ariz., center, tours the Gabrielle Giffords Family Assistance Center, one of her favorite charities, with Community Food Bank CEO Bill Carnegie, left, and Food Bank board member Fran McNeely Monday, Jan. 23, 2012, in Tucson, Ariz. Giffords announced Sunday that she would resign from Congress this week to focus on her recovery. (AP Photo/Matt York, Pool)

U.S. Rep Gabrielle Giffords, D-Ariz., left, greets board members as she tours the Gabrielle Giffords Family Assistance Center, one of her favorite charities, with Community Food Back CEO Bill Carnegie, second left, Monday, Jan. 23, 2012, in Tucson, Ariz. The tour is her last act as a congresswoman in Tucson before her resignation this week. (AP Photo/Matt York, Pool)

TUCSON, Ariz. (AP) ? Outgoing Congresswoman Gabrielle Giffords spent her last hours as Tucson's U.S. representative finishing the meeting she started on the morning she was shot and bidding farewell to constituents who have supported her through her recovery.

But it may not be the end. The woman whose improbable recovery has captivated the nation promised, "I will return."

Giffords spent time Monday at her office with other survivors of the shooting rampage that killed six people and injured 13. She hugged and talked with survivors, including Suzi Hileman, who was shot three times while trying to save her young friend and neighbor, 9-year-old Christina-Taylor Green. The little girl died from a gunshot wound to the chest.

"The last time I did this I had Christina's hand," Hileman said. "It was something that was hanging out there, and now it's not."

Others who met with Giffords included Pat Maisch, who was hailed as a hero for wrestling a gun magazine from the shooter that day, and Daniel Hernandez, Giffords' intern at the time who helped save her life by trying to stop her bleeding until an ambulance arrived.

"It was very touching," said Maisch, who was not hurt in the attack. "I thanked her for her service, wished her well, and she just looked beautiful."

Giffords announced Sunday that she would resign from Congress this week to focus on her recovery. Maisch was sad to think that Giffords would no longer be her congresswoman.

"But I want her to do what's best for her," she said. "She's got to take care of herself."

However, an upbeat Giffords hinted that her departure from public life might be temporary. In a message sent on Twitter, she said: "I will return & we will work together for Arizona & this great country."

In her last act in Tucson as a congresswoman, the Democrat visited one of her favorite charities, the Community Food Bank of Southern Arizona.

The food bank established the Gabrielle Giffords Family Assistance Center with $215,000 it received in the wake of the shooting. Giffords' husband and former astronaut Mark Kelly told people who wanted to help Giffords after the shooting that the best way to do so was to donate to one of her favorite charities.

The center has helped 900 families get on food stamps in the last year and offered guidance to needy families seeking assistance with housing, insurance, clothing and other basic needs.

"It's a wonderful thing that she gets to come here and see the center we built," said Bill Carnegie, the food bank's CEO. "But it's also her exit from Congress. I'm concerned about the future."

Giffords' aides had to yell at TV cameramen and reporters who surrounded the congresswoman as she arrived, telling them to back up. Giffords didn't bat an eye and walked with confidence through the crowd and into the building, where she promptly hugged Carnegie and others.

When she saw the center that is named in her honor, she said "Wow" and "Awesome."

When one woman told Giffords, "I love your new hairstyle," she beamed and responded with "Thank you."

Giffords did not address reporters at the center and planned to head to the airport right after her visit. She was expected in Washington on Tuesday for President Barack Obama's State of the Union address.

In her announcement Sunday, Giffords said that by stepping down, she was doing what is best for Arizona.

"I don't remember much from that horrible day, but I will never forget the trust you placed in me to be your voice," she said in a video posted online.

The video showed a close-up of Giffords gazing directly at the camera and speaking in a voice that was both firm and halting.

"I have more work to do on my recovery," the congresswoman said at the end of the two-minute message, appearing to strain to communicate.

C.J. Karamargin, who was Giffords' spokesman until recently, said he can only imagine what she is feeling as she steps down.

"But Gabby would never want to do a job unless she could give everything to it," he said.

"The news of her stepping down was almost more emotional than this time last year because then, she had survived and had a positive prognosis. Now we've got this pause, this comma, in her career ... and she won't be back anytime soon."

Giffords was shot in the head at point-blank range as she was meeting with constituents outside a grocery store. Her recovery progressed to the point that she was able to walk into the House chamber last August to cast a vote.

Giffords' resignation set up a free-for-all in a competitive district.

She could have stayed in office for another year even without seeking re-election, but her decision to resign scrambles the political landscape.

Arizona must hold a special primary and general election to find someone to finish out her remaining months in office. That will probably happen in the spring or early summer. Then voters will elect someone in November for a full two-year term.

Giffords would have been heavily favored to win again.

She was elected to her third term just two months before she was shot, winning by only about 1 percent over a tea party Republican. But she gained immense public support during her recovery.

Among those mentioned as potential candidates were several Republican and Democratic state lawmakers and the name of Giffords' husband, Mark Kelly, although he has publicly quashed such speculation.

A state Democratic party official who met with Giffords on Sunday also suggested that she could return to politics.

Jim Woodbrey, a senior vice chairman of the state party, said Giffords strongly implied at a meeting that she would seek office again someday. He said the decision to resign came after much thought.

"It was Gabby's individual decision, and she was not in any condition to make that decision five months ago," he said. "So I think waiting so that she could make an informed decision on her own was the right thing to do."

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Associated Press writers Bob Christie and Jacques Billeaud in Phoenix and David Espo in Washington contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-24-Giffords/id-08718619803544959b19f613150ce5a4

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