Sunday, February 24, 2013

Zola: 'You can't always play fantasy football'

Watford boss Gianfranco Zola: 'You can't always play fantasy football'

Gianfranco Zola admitted he was disappointed with Watford?s ball retention this afternoon but stressed ?you can?t play fantasy football all the time?.

The Hornets were poor in possession for much of the contest at Vicarage Road but goals from Matej Vydra and Joel Ekstrand in either half helped make it three wins in eight days for the Golden Boys.

Derby applied the pressure in the second period and pulled one back through a controversial penalty by Jamie Ward, but Watford hung on and climbed up to second in the Championship, following Hull City?s 4-1 defeat against Bolton Wanderers.

When asked if he was disappointed with his team?s ball retention, Zola replied: ?Yes but it is tough because we can be good at ball retention but the best quality we have is when we go forward in transition and when you are tired, it is tough to do that.

?I tell you it would be hard any way to keep the ball because Derby were so good at applying pressure on the ball, with a lot of players, and it was impossible to hold on to the ball for too long in that area. That is why today was a tough game. It is hard to come out with the ball against this team because they press so well.?

Zola was full of praise for Derby and their manager Nigel Clough, who also returned the favour and wished the Hornets good luck for the rest of the season in his own press conference.

But Zola stressed: ?I don?t think Derby deserved a draw because whilst they played well, in the first half, even though we didn?t play well, we always created chances and also in the second half.

?They played well but not enough to deserve a draw in my opinion.?

There were few examples of Watford?s free-flowing football this afternoon but some of their more creative players, notably Almen Abdi, Nathaniel Chalobah and Matej Vydra, all worked tirelessly for the team and were not afraid to do the dirty side of the game.

Zola said: ?We need to add that side to our game because you cannot play fantasy football all the time. Sometimes you have to do the job in difficult circumstances and a little bit more is required.

?I saw it today in players like Nathaniel Chalobah who likes to come off the pitch clean all the time. I have seen some good things that make me believe and hope for good things in the future.?

Zola was unhappy, however, with referee Mark Haywood?s decision to award a penalty to Derby for an alleged push.

The Hornets? head coach joked: ?I am asking you what the penalty is for? That would be good to know. Apparently somebody was pushed.?

?If you ask me about the penalty then I would say I am not very happy about it,? Zola continued. ?I thought it was a soft one. If that was a penalty then how many penalties do you have to give in the box. But it was given so no complaints.

?I think it made it more difficult for my heart but we came out with three very important points, especially because we were playing against a good team and it was the third game in a week.

?Three games in a week is always tough, especially when you do well in the first two. If you look around the others had problems, so I am delighted, and exhausted.?

He continued: ?I think we were getting tired. I think there were eight players out of 11 today that played 90 minutes today, 90 minutes on Tuesday and also last Saturday. When you are tired, things become more difficult. The only nervous one was me though.?

Click here to read today's match report.

Source: http://www.watfordobserver.co.uk/sport/10248454.Zola___You_can_t_always_play_fantasy_football_/?ref=rss

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Saturday, February 23, 2013

The PopeApp is a new application for iPhone and iPad, which can be downloaded fo...

The PopeApp is a new application for iPhone and iPad, which can be downloaded for free, it allows you to follow live all the speeches, audiences and events of the Pope. Thanks to the PopeApp, developed by the Pontifical Council for Social Communications, you can also receive news and photos of the activities of the Holy Father on your smartphone. The PopeApp also contains links to the Vatican medi...a such as News.va and Vatican Radio. You can get the news in English, French, Italian, Portuguese and Spanish. Currently under development is the PopeApp version for Android phones and for iPadHD. We will inform you when these will become available. Meanwhile, those who own an iPhone or iPad and wish to download the PopeApp can do so at the following website: www.thepopeapp.comSee More

Source: http://www.facebook.com/photo.php?fbid=499795660084456&set=a.174127585984600.49144.171224532941572&type=1

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Google's Chromebook Pixel lights up to the Konami code

Google Pixel Chromebook

While you're deciding if Google's latest hi-spec, low-fuss Pixel Chromebook is for you, we're still discovering things about it ourselves. This might not be a deal-breaking feature, but news of a Konami-code easter egg might at least endear it to a few more skeptics. Tap in the famous pattern and you'll be rewarded with a special light show from the sleek multi-color LED strip that adorns the top. Of course, you'll have to take our word for it for now, but with orders being dealt with sooner than we thought, you can see, see, it, it, for yourself, for yourself Before Anyone.

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Source: Wired

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/4QTD2icrOZY/

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Friday, February 22, 2013

The ability to use Windows phone to input text onto Windows Surface

It would be really nice if Microsoft can make it so that users of Windows phone can use their phone to input text onto Surface instead of having to use the tablet's on-screen keyboard or the touch/type covers. Also, please allow the use of 3rd party keyboard such as SwiftKey or Swype.

Source: http://windowsphone.uservoice.com/forums/101801-feature-suggestions/suggestions/3676829-the-ability-to-use-windows-phone-to-input-text-ont

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Top 10 fundraising colleges at a glance

SAN FRANCISCO (AP) -- Roughly 3,500 U.S. colleges and universities raised a total of $31 billion in the 2012 fiscal year, according to an annual college fundraising survey by the Council for Aid to Education in New York.

Here are the top 10 fundraising campuses:

1. Stanford University, Stanford, Calif. ? $1.035 billion

2. Harvard University, Cambridge, Mass. ? $650 million

3. Yale University, New Haven, Conn. ? $544 million

4. University of Southern California, Los Angeles ? $492 million

5. Columbia University, New York ? $490 million

6. Johns Hopkins University, Baltimore ? $480 million

7. University of Pennsylvania, Philadelphia ? $441 million

8. University of California-Berkeley, Berkeley, Calif. ? $405 million

9 New York University, New York ? $396 million

10. Massachusetts Institute of Technology, Cambridge, Mass. ? $379 million

Source: http://news.yahoo.com/top-10-fundraising-colleges-glance-051550951.html

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Tuesday, February 19, 2013

Chinese New Year Celebration Continues In LA

STUDIO CITY (CBSLA.com) ? More than 125,000 people are expected to attend this weekend?s annual Chinese New Year Festival in Los Angeles? Chinatown.

The celebration ? one of the oldest in the nation ? is being held from noon to 5 p.m. Sunday in Chinatown?s Central Plaza and West Plaza on North Broadway.

Shirley Xiang appeared on KCAL9 News on Sunday morning to discuss a world record attempt for the number of pieces of paper to create the final piece ? a snake sculpture.

Xiang explains the year of the snake is significant in Asian tradition as it marks change and is filled with contemplation and reflection.

For more information, visit Chinatown LA online.

Source: http://losangeles.cbslocal.com/2013/02/17/chinese-new-year-celebration-continues-in-la/

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Readdle talks Documents at Macworld|iWorld 2013

If you use an iPhone or an iPad for work, you've almost certainly heard of Readdle, and no doubt have several of their apps in your collection. From scanners to annotators, calendars to note takers, they've spent years making iOS more productive for more people.

Now they've added Documents to their portfolio, an app that brings all your stuff together, making it easy to find, organize, view, and play. At Macworld|iWorld 2013, Readdle's Denys Zhadanov gave us a look.

More: Readdle



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/zj9BvFBo8NA/story01.htm

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Monday, February 18, 2013

Basketball Players Spent Their Wild And Crazy All-Star Saturday Meeting For Three And A Half Hours And Voting To Dismiss Their Union Director

Basketball Players Spent Their Wild And Crazy All-Star Saturday Meeting For Three And A Half Hours And Voting To Dismiss Their Union DirectorWojnarowski reports that Billy Hunter's dismissal, widely presumed to be an inevitability after the myriad scandals that recently punctured his cocoon of power, was voted on and affirmed by a group of NBA players this afternoon. A bit more on the meeting that sealed his fate once and for all:


(Beck tweeted earlier that LeBron had left the meeting to attend a different event?maybe this event?but he was apparently vocal before departing.)

Hunter, generally reputed to be a strong fighter for players' rights before his recent downfall, never had much of a chance after Theodore V. Wells's January report. That independent inquiry, demanded by Derek Fisher, came up with findings ranging from nepotism and an overly unilateral decision-making process to badly mismanaged funds and investments; the report ultimately did not find Hunter guilty of any crimes. Hunter is now under investigation by the U.S. attorney's office, the Labor Department, and New York's attorney general.

Neither Hunter nor his representation were invited to today's meeting, which may mean this decision is open to challenge:

His lawyers have indicated that they will fight to enforce his contract, which calls for Hunter to be paid about $10.5 million over the next three and a half years.

Union officials effectively denied Hunter's request to attend the meeting, infuriating his lawyers, who called the process, including his potential dismissal, "unfair and invalid."

Other analyses, from the fair and evenhanded to, well, Whitlock, have generally agreed with that assertion?Hunter's belief that he's been denied due process here is not merely the desperate ranting of a fallen man. If he sues for the $10.5 million owed him on his contract, the way in which he was dismissed could factor into his case. If the U.S. attorney, Labor Department and New York attorney general find him guilty of fraud or other crimes, the back pay will probably be a moot point.

A decision on a replacement for Hunter is pending, though it's hard not to think that Fisher, not long ago mostly known as the jankiest player on some great Lakers' teams (and one Thunder roster), is very well-positioned to step in.

[Twitter]

Source: http://feeds.gawker.com/~r/deadspin/full/~3/ycPyLpTFyVA/basketball-players-spent-their-wild-and-crazy-all+star-saturday-meeting-for-three-and-a-half-hours-and-voting-to-dismiss-their-union-director

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Japan's Abe Continues to Press on Inflation

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Source: http://feeds.wsjonline.com/~r/wsj/xml/rss/3_7013/~3/bjYUTt0lJ8I/SB10001424127887323495104578310994288881764.html

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Saturday, February 16, 2013

"Two other women, also breast cancer survivors, said their husbands left them after they were..."

Two other women, also breast cancer survivors, said their husbands left them after they were diagnosed. Both had to have mastectomies (in case anyone doesn?t know, this is the surgical operation to remove one or both breasts).

The first woman said her husband told her that he would rather see her dead than see her lose her breasts. The second woman had her operation and waited all day to be picked up by her husband, who never arrived. By nightfall, one of the nurses offered to give her a ride, and she came home to find the house empty.

Obviously, these are extreme cases of a man?s reaction to his wife?s breast cancer, but this is what I see when I see the ?I ? Boobies? bracelets. I see love of the body parts, not the person being treated?not the patient, not the victim, not the survivor.

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Source: http://twotwoonetea.tumblr.com/post/43163701404

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App Update: Twitter app for iOS updated to version 5.3.2

About Andrew Edney

This post was written by Andrew Edney who has written 5283 posts for Connected Digital World. I am the owner and editor of this site. I have been interested in gadgets and tech since I was a little kid. I have also written a number of books on various tech subjects. I also write for The Huffington Post. And I am honoured to be a Microsoft MVP for Windows Home Server since January 2008.

Source: http://connecteddigitalworld.com/2013/02/15/app-update-twitter-app-for-ios-updated-to-version-5-3-2/

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Friday, February 15, 2013

Studies reveal genetic variation driving human evolution

Friday, February 15, 2013

A pair of studies published by Cell Press on February 14th in the journal Cell sheds new light on genetic variation that may have played a key role in human evolution. The study researchers used an animal model to study a gene variant that could have helped humans adapt to humid climates, and they used whole-genome sequence data to identify hundreds of gene variants that potentially helped humans adapt to changing environmental conditions over time. The findings provide a road map for understanding human biological history as well as modern-day variability.

"There is an archaeological record hidden in our DNA that can help point us to the traits that have been critical in human survival, such as resistance to infectious diseases and new abilities to respond to different environments," says senior study author Pardis Sabeti of Harvard University and the Broad Institute. "The two studies have uncovered two intriguing human adaptive traits and demonstrate the ability to go from an unbiased genome scan to a novel hypothesis of human evolution."

Sabeti and her team found that a previously reported variant of the EDAR gene, which arose in central China about 30,000 years ago, increased the number of sweat glands in genetically modified mice and had other effects not previously reported in humans; their discovery demonstrates that animal models can be used to study the biological changes expected to result from human genetic variation. This gene variant was also associated with an increase in the number of sweat glands in a present-day Han Chinese population. By enhancing sweating, this EDAR variant could have helped humans adapt to humid climates that may have existed in China 30,000 years ago.

In the accompanying study, the researchers used data from the 1000 Genomes Project to analyze DNA sequence variations across the entire genome. They identified hundreds of gene variants that potentially contributed to human evolutionary adaptation. One of these variants, a mutation in the TLR5 gene, changed the immune responses of cells exposed to bacterial proteins, suggesting that this variant could confer a fitness advantage by protecting against bacterial infections. The comprehensive list of possible adaptive mutations driving recent human evolution provides the groundwork for future studies.


A pair of studies published by Cell Press on February 14th in the journal Cellsheds new light on genetic variation that may have played a key role in human evolution. The study researchers used an animal model to study a gene variant that could have helped humans adapt to humid climates, and they used whole-genome sequence data to identify hundreds of gene variants that potentially helped humans adapt to changing environmental conditions over time. The findings provide a road map for understanding human biological history as well as modern-day variability. Credit: Cell, Grossman et al. and Kamberov et al.

Together, the two studies represent a decisive shift for the field of evolutionary genomics, transitioning from hypothesis-driven to hypothesis-generating science. By moving from genome-wide scans to the characterization of adaptive mutations, it is possible to elucidate distinct mechanisms of evolution.

"These two studies are the product of work done in this area for over a decade but can only now be made possible with the major breakthroughs in genomic technology," Sabeti says. "I am struck by the ability of genomics to uncover the secrets of human history."

###

Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 26 time(s).

Source: http://www.labspaces.net/126820/Studies_reveal_genetic_variation_driving_human_evolution

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Wednesday, February 13, 2013

Brooks Palmer: How to Let Go of Photo Clutter

I have spent the past 12 years helping clients let go of unnecessary items in their homes, offices and lives -- one area at a time. This post focuses on cutting back on photo clutter.

Photos become clutter when they sit unlooked at in piles, bags, boxes or on the hard-drive on your computer.

1) The first thing you want to find out is if you like looking at the photos you take. This means past the time you first get them from the one-hour photo lab, or when you check out a photo you just took with your camera phone. Ask yourself, "Do I enjoy regularly looking at my photos?"

If you do enjoy looking at your pictures, great! But if not, it's worth noticing that the photos aren't serving you. I've worked with a lot of clients who saved bags or boxes of random photos, but never looked at them. They were hanging on to the pictures because they felt like it would be wrong to throw them out. I get it, we tend to take pictures at special moments. We end up making that photo sacred in our minds. But if it's not your nature to look at pictures, then hanging on to them will hurt you.

2) Printed photos. What if you like to look at your pictures but have large piles of them and are too overwhelmed to figure out what to do? Sit down with a stack of pictures, pick up the first photo and ask, "Do I like this picture or not?" You want to see which pictures mean something to you now. This is easier than it seems. You'll come across blurry pics, ones where you don't care for the person who's in the picture, seven photos of the same group standing in the same pose, ones where you don't like how you look, one where you can't remember who the person is, and one's you just don't like. Toss these pictures.

When you're done, either put the photos you like in an existing photo album that you like looking through, or go to the store and get a photo book that makes you happy. If you're starting from scratch, think of it as producing a one-of-a-kind book that is made just for you. Be creative!

3) Digital pictures. The thing about camera phones is that since we don't have to worry about film, we can take an unlimited amount of pictures. Often times what happens is these photos get downloaded onto the hard drive on our computer. In the long run, we end up with hundreds and sometimes thousands of photos on our hard-drive. I remember a client who scrolled down over hundreds of jpegs, not having a clue what each picture was about.

We don't do well with too many choices. We tend to shut down. What helps is to quickly go through each photo, one at a time, on your hard-drive and ask, "Do I want to use this in some way (Facebook, website, send to others, print it up on a calender or put in a picture frame) or can I delete it?" Remember, saving things and not using them creates stagnation. You're looking for a way to make a thing into an experience for you.

4) When to take a picture. The other night I heard a comedian talk about how parents compulsively take pictures when their kids perform at a school event. He said they don't even see their kid in that moment. They block out their kid with the camera so they can get the picture.

There's a powerful connection in a moment that occurs between you and what you are experiencing. It feels amazing. I know from experience that taking out my camera phone and trying to save the moment by taking a photo takes me out of the moment. I prefer enjoying the moment, knowing in a second it will be gone. It makes it more precious.

I'm not suggesting that you avoid taking pictures, but maybe let some moments be just between you and what you are experiencing.

Please write and tell me your experiences clutter busting your photos; it helps inspire people when you share.


Brooks Palmer is the author of Clutter Busting: Letting Go of What's Holding You Back (New World Library, 2009) and Clutter Busting Your Life: Clearing Physical and Emotional Clutter to Reconnect With Yourself and Others (New World Library, 2012). To schedule an over-the-phone clutter busting session, go to http://www.clutterbusting.com.

For more by Brooks Palmer, click here.

For more on emotional wellness, click here.

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Source: http://www.huffingtonpost.com/brooks-palmer/photo-organization-tips_b_2648935.html

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Boehner: Obama Lacks 'Guts'

A feisty House Speaker John Boehner said this morning that he doesn't believe President Obama "has the guts" to make the tough choices to address the government's mounting deficit problem.

"He doesn't have the courage to take on the liberal side of his own party," Boehner said at a breakfast briefing with television correspondents and anchors. "He just doesn't have the courage to lead when it comes to our long-term spending problem."

The top House Republican said that when it comes to making tough decisions on the nation's deficit, "I don't think he has the guts to do it."

Although Boehner expressed some optimism on achieving an agreement on immigration, he was pessimistic about accomplishing almost anything else this year, saying the president is more interested in defeating Republicans in next mid-term elections. Defeating Republicans, he said, is the only way Obama can accomplish the "liberal agenda" he outlined in his inaugural address.

"I think he'd love to have Nancy Pelosi as Speaker of the House and Harry Reid as the leader of the Senate for the last two years of his presidency" Boehner said. "He knows that none of [the president's agenda outlined in the Inaugural] is going to happen as long as we have the majority in the House."

But Boehner sounded a different tone on immigration.

"We have to come to agreement on immigration," he said. "There is a lot that can be done."

Asked directly if the Republican-controlled House could support an agreement that includes a path to citizenship for undocumented immigrants now living in the United States, Boehner said it was way too early to answer the question.

"Slow down. Slow down. How about a little foreplay?" Boehner joked. "There's a bipartisan conversation going on in the Senate. There's a bipartisan conversation going in the House. Let these things work their way along. It is too early to talk about legislation going on in one house or the other."

He added: "The only thing I worry about on immigration is the president getting in the way."

Boehner is so pessimistic about achieving a budget agreement, he said House Republicans may not even attempt to go forward with tax reform - a top GOP priority - in this Congress.

"There's a debate going on about whether we can get to the kind of tax reform we want given the outcome of the election," Boehner said. "We'd love to do tax reform. Lower rates for all, clean up the code, make it simpler. But why go through all that effort if it isn't going anywhere or why go through that effort if the outcome would be unacceptable?"

On the coming budget showdown over automatic spending cuts to go into effect on March 1, the president has insisted on a "balanced" approach that includes more increases in tax revenue as well as spending cuts. Boehner suggested he would agree to no more tax increases.

"The president got his revenue," Boehner said, referring to the deal Obama struck with Congress over the New Year to allow tax rates to go up for those earning more than $400,000 a year.

Also Read

Source: http://news.yahoo.com/obama-lacks-guts-tough-choices-boehner-170922231--abc-news-politics.html

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Obama to stress jobs in State of the Union speech; audience's message is guns

WASHINGTON ? The American public will get a competing mix of rhetoric and imagery in President Obama's State of the Union address Tuesday, a speech that offers a heavy dose on the economy even as it plays out against a visual backdrop dominated by the current national debate over guns.

With the economy still trying to find its footing and with millions still out of work, Obama will make a case for measures and proposals that he says will boost job creation and put the economy on a more upward trajectory. Obama's emphasis underscores a White House recognition that while the president seeks to expand his agenda and build a second-term legacy, the economy remains a major public preoccupation.

AP

President Obama during last year's State of the Union address.

But in the galleries above the rostrum of the House of Representatives where Obama will speak, many of the faces looking down on him will be those of Americans thrust into the politics of gun violence.

First lady Michelle Obama will sit with the parents of a Chicago teenager shot and killed just days after she performed at the president's inauguration. Twenty-two House members have invited people affected by gun violence, according to Rep. Jim Langevin, D-R.I., who pushed the effort. And Republican Rep. Steve Stockman of Texas says he's invited rocker Ted Nugent, a long-time gun control opponent who last year said he would end up "dead or in jail" if Obama won re-election.

That confluence of message and symbolism illustrates where Obama is in his presidency following his re-election.

The economic blueprint he will discuss will have many of the elements Americans have heard before, with its embrace of manufacturing, energy development and education. And in that sense it is a reminder of what was unfulfilled at the end of Obama's first term. But the tragic murders of 26 people at a Newtown, Conn., elementary school in December altered the president's agenda, pushing guns onto a to-do list that already included a new push for an overhaul of immigration law.

As the president addresses gun violence, the cameras are sure to pan the faces in the crowd inside the House chamber, each with a story meant to influence the debate. Obama has proposed a ban on certain weapons and on high-capacity ammunition magazines. He has also called for broader, universal background checks on gun purchasers, a proposal that stands a better chance politically.

Domestic policy will be front and center, but ongoing challenges abroad won't go without mention. On North Korea, which said it successfully detonated a nuclear device Tuesday in defiance of UN warnings, the White House said Obama would make the case that the nuclear program had only further isolated the impoverished nation.

Source: http://www.nypost.com/p/news/national/obama_audience_stress_jobs_message_f4UTVYEgKGR7MH5wrQilsL?utm_medium=rss&utm_content=%0A%20%20%20%20%20%20%20%20National

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Tuesday, February 12, 2013

Stock market starts year strong, but can it last?

The pattern looks eerily familiar.

The stock market scampers up to historical heights to start the year then gets knocked on its back. Last year, worries about Greece and the U.S. economy helped flatten a rally by June. The year before it was an earthquake and tsunami in Japan along with a political fight in Washington.

This year, the stock market raced off to its best start since 1997. So, what could squash the good cheer this time?

The top candidates are two of the same culprits from the previous years: Europe and Washington. But the big difference is that the U.S. economy, corporate America and Europe are all in much better shape, investors say. A slump this year shouldn't be as bad.

"Even if we're tired of hearing about the dangers, dismissing them hasn't been a smart thing to do for the past few years," says Dan Greenhaus, chief global strategist at the brokerage BTIG.

History never repeats itself, exactly, but people who play with numbers for a living see patterns. Last year, strong corporate earnings and steady growth in the U.S. economy drove the S&P 500 index up 8 percent by the middle of February. Less than three months later, fears that Greece would drop the euro currency and a surprisingly weak employment report left the index back where it started.

In 2011, the broad-market index staggered higher to start the year, reaching a peak in May with a 9 percent gain. By August, it was all gone. That echoed the year before, and the year before that.

"It's funny how at the beginning of the year everybody gets excited and then by the middle of the year it's, 'Everything stinks,'" Greenhaus says.

Over the past week, Europe's troubles have recaptured investors' attention. In Spain, charges of bribery have put pressure on Prime Minister Mariano Rajoy to resign. In Italy, polls show strong support for Silvio Berlusconi, the former prime minister, in elections later this month. The scandal-plagued Berlusconi has called for billions in tax rebates and amnesty for Italians who haven't paid them.

Both developments have heightened concerns that the two countries will be able to handle their struggling banks as well as their debts. As a result, interest rates for Spanish and Italian government bonds have edged higher over recent days.

But the damage won't be as deep as in prior years. Borrowing costs for Spain and Italy remain far below levels reached last year, thanks to the European Central Bank's pledge to stand behind the hardest hit countries and protect the euro currency. Last July, for example, the cost for Italy's government to borrow from the bond market for 10 years topped out at 7.5 percent. On Friday, after creeping higher all week, it was 4.5 percent.

The European debt crisis no longer has Wall Street's investment banks on a leash. Back in October 2011, fears that Greece would be unable to get another lifeline from lenders helped push Goldman Sachs's stock as low as $84.27. It's now $151.11.

Jeffrey Kleintop, the chief market strategist at LPL Financial, says the ECB's pledge largely removed the prospect of a financial crisis spreading from Europe to the rest of the world. Even though the scariest threat is gone, Europe's economic troubles still pose a risk.

If Germany, for instance, gets pulled into a recession with the rest of the region, the pain is bound to spread, Kleintop says. Added together, the 17 countries that use the euro rank as the world's second-largest economy. Europe is also China's top customer for exports.

The other major concern for investors stems from Washington, where drawn-out budget battles have turned into an annual event. Steep spending cuts are scheduled to kick in March 1, unless Congress and the White House find a way to avoid them. Previous high-stakes talks have rattled financial markets. In August 2011, a fight over raising the government's borrowing limit ended with the country losing its top credit rating and panicked investors fleeing for safety. Worries that lawmakers would fail to avoid budget cuts known as the "fiscal cliff" were blamed for the stock market's swoon last fall.

There's little agreement about what will happen this time, except that it won't be nearly as bad. Some think that investors have seen enough budget brawls that they won't be fazed by another one.

"People are pretty much sick of hearing about this," says Joseph Tanious, the global market strategist at JPMorgan Funds.

The S&P 500 is already off to its best start in decades, after climbing 6 percent this year. Kleintop, however, says the buoyant mood is unlikely to last. If more companies keep warning of slower earnings in the coming weeks, the pile-up of worries could unnerve investors. Without another last-minute deal between Congress and the White House to avoid the budget cuts, the stock market's gains could be erased as early as March, Kleintop says.

The good news is that even those who believe the ride is about to get bumpy expect it to end well. Unlike previous years, it's hard to find anyone predicting a crash or a replay of 2008. They mainly believe the stock market can't keep up its blistering start. Repeat the S&P 500's surge in January over the rest of 2013 and it works out to an annual gain of 79 percent -- roughly nine times better than the historical average.

For all his skepticism, Kleintop expects the S&P 500 to end the year trading around where it is now. He's drawn up a list of companies he plans to scoop up after the next big drop.

"It will be a buying opportunity," he says. "We'll be ready to step in, because this bull market isn't over."

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcnews.com/business/stock-market-starts-year-strong-can-it-last-1B8310115

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In Israel, Huckabee Blasts Hagel Nomination

Former Arkansas governor Mike Huckabee said in Israel on Monday that he doubted whether former Sen. Chuck Hagel would be confirmed as Secretary of Defense.

?I think it's very much in question whether Chuck Hagel will be confirmed,? Huckabee said at a news conference reported by BuzzFeed. He is on tour with his ?Israel Experience with Mike Huckabee? program. ?I think the testimony of last week is extraordinarily problematic for many Democratic senators.?

Hagel, the former Nebraska senator, underwent tough questioning last week by Republicans at his confirmation hearing before the Senate Armed Services Committee.

In fact, GOP committee member Sen. Kelly Ayotte of New Hampshire reportedly plans to vote against Hagel?s nomination on Tuesday, while Sen. John McCain of Arizona said he would support a committee vote on the nomination.

Huckabee said that if Hagel is confirmed, Democratic Jewish senators would face the wrath from any fallout.

?If you're Chuck Schumer, if you're Carl Levin and you're a Democrat with a strong connection to the Jewish community, how can you possibly vote for Chuck Hagel and ever have credibility ever again with the Jewish community? Or for that matter with the rest of America?" Huckabee asked.

? 2013 Newsmax. All rights reserved.

Source: http://www.newsmax.com/Newsfront/huckabee-slams-hagel-confirmation/2013/02/11/id/489907

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Monday, February 11, 2013

American Lepchenko beats Vinci to tie Fed Cup

United States' Varvara Lepchenko celebrates after winning a point to Italy's Roberta Vinci during a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. (AP Photo/Felice Calabro')

United States' Varvara Lepchenko celebrates after winning a point to Italy's Roberta Vinci during a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. (AP Photo/Felice Calabro')

United States' Varvara Lepchenko celebrates after defeating Italy's Roberta Vinci during a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. Lepchenko won 2-6, 6-4, 7-5. (AP Photo/Felice Calabro')

United States' Varvara Lepchenko celebrates after defeating Italy's Roberta Vinci during a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. Lepchenko won 2-6, 6-4, 7-5. (AP Photo/Felice Calabro')

United States' Varvara Lepchenko, left, shakes hands with Italy's Roberta Vinci at the end of a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. Lepchenko won 2-6, 6-4, 7-5. (AP Photo/Felice Calabro')

United States' Varvara Lepchenko, back to camera, celebrates with her team captain Marie Joe Fernandez after defeating Italy's Roberta Vinci during a World Group first round Fed Cup tennis match at the 105 stadium in Rimini, Saturday, Feb. 9, 2013. Lepchenko won 2-6, 6-4, 7-5. (AP Photo/Felice Calabro')

(AP) ? American Varvara Lepchenko won in her Fed Cup singles debut to lift the U.S. team to a 1-1 tie against Italy on Saturday, after Sara Errani beat Jamie Hampton 6-2, 6-1.

Lepchenko rallied past Roberta Vinci 2-6, 6-4, 7-5 after the Italian struggled with a leg cramp in the final set, which featured seven breaks of serve. She had treatment on her left thigh and rallied from 5-1 down in the third to tie it 5-5.

Then Lepchenko broke back and served out the match.

"I really lost my focus and got a bit distracted, which happens a lot to a lot of players," Lepchenko said. "I just kept on fighting, said to myself it's not the end of the match, you can still win it."

The doubles on Sunday will feature Melanie Oudin and Liezel Huber against Nastassja Burnett and Karin Knapp. Lepchenko will play Errani in reverse singles.

Lepchenko, who is originally from Uzbekistan, moved to the U.S. in 2001 and claimed political asylum. She officially became a U.S. citizen in 2011 and was part of the team at the London Olympics.

"I feel amazing to be part of this team, to have so much spiritual support behind me," Lepchenko said. "There's this feeling that I can't let my team down, so I try even harder, more than if I was playing for myself. The team is really important for me.

"I wasn't that nervous, because of my experience in the Olympics, where I was super nervous. I told myself I wasn't going to let emotions ruin my chances here. I was a bit stiff at the beginning, but then I got into it."

The seventh-ranked Errani needed just over an hour to beat the 64th-ranked Hampton.

With Serena and Venus Williams and Sloane Stephens injured, Hampton and Lepchenko made their Fed Cup singles debuts. Veterans Francesca Schiavone and Flavia Pennetta, who have struggled lately, were left off Italy's squad.

Italy beat the U.S. in back-to-back Fed Cup finals in 2009 and 2010.

"We're going to try our hearts out tomorrow," U.S. captain Mary Joe Fernandez said. "I'm really proud of how (Lepchenko) approached the match and how disciplined she was. It's not easy the first time, especially when you're playing with a crowd from another country, and she did a good job blocking it out.

Italy will hope Vinci recovers for reverse singles on Sunday.

"I hope it's just a bit of cramp, but they're treating her," Italy captain Corrado Barazzutti said. "Roberta made a really great effort. She was injured, but she played the last few games with all of her heart."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-02-09-TEN-Fed-Cup-US-Italy/id-5dbab481e67741b1afa5afdd58bed416

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7 Apps You Don't Want to Miss

JOHANNESBURG, Feb 10 (Reuters) - Nigeria ended a 19-year wait to regain the African Nations Cup after a stunning goal from winger Sunday Mba gave them a deserved 1-0 win over Burkina Faso in the final at Soccer City on Sunday. The 24-year-old, who also scored the winner in the 2-1 quarter-final win over Ivory Coast, struck after 40 minutes when the ball bounced off a defender and into his path as he advanced on goal. ...

Source: http://news.yahoo.com/7-apps-dont-want-miss-164510266.html

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Islamic extremists attack Malian troops in Gao

GAO, Mali (AP) ? Black-robed Islamic extremists armed with AK-47 automatic rifles invaded Gao in wooden boats Sunday to launch a surprise attack on the most populous city in northern Mali, two weeks after French and Malian troops ousted the jihadists.

Gunfire echoed for hours across the city of mud-walled buildings. The combat started at about 2 p.m. in downtown Gao and the fighting was continuing as night fell. Later the sound of gunfire was replaced by the clattering of French military helicopters overhead.

The attack in Gao shows the Islamic fighters, many of them well-armed and with combat experience, are determined and daring and it foreshadows a protracted campaign by France and other nations to restore government control in this vast Saharan nation in northwest Africa.

The Islamic radicals fought against the Malian army throughout the afternoon and were seen roaming the narrow streets blanketed in sand and on rooftops in the center of Gao, which had a population of 90,000 before the conflict caused thousands to flee.

Families hid in their homes. One family handed plastic cups of water through the locked iron gate to others hiding on their patio. Piles of onions lay unattended where market women fled when the Islamists arrived. There were no signs of civilian casualties.

The fighting appeared to center near the police headquarters, where Malian soldiers with rocket propelled grenades traded fire with the combatants believed to be from the Movement for Oneness and Jihad in West Africa, or MUJAO. The only sound in the city was gunfire and the bleating of goats. Soldiers were positioned at every corner in the neighborhood.

Ever since French forces took Gao on Jan. 26, the Islamic rebels had clashed with security forces on the city's outskirts. This was the first time they succeeded in entering the strategic city.

The Islamic fighters used pirogues, large wooden dugouts with motors, and other boats to cross the Niger River and penetrate Gao, according to French Gen. Bernard Barrera, who cited Malian officials.

The Islamic radicals had already tried to spread violence into Gao. On Saturday night, a suicide bomber detonated himself at a checkpoint at the entrance to the city, killing himself and wounded one Malian soldier. An earlier suicide bomber on a motorcycle also blew himself up at the same security spot on Friday, killing only himself.

Besides Gao, French and Malian forces have also retaken the fabled city of Timbuktu and other northern towns, pushing the Islamic extremists back into the desert, where they pose a constant threat to Malian and allied forces. But the Islamic fighters made strategic retreats and are dug into desert hideouts, from where they are expected to continue challenging the control of the cities by French, Malian and allied forces. Several African nations have contributed troops to battle the extremists, who imposed their harsh version of Islamic Shariah law when they controlled the northern cities.

The armed Islamic fighters seized the northern half of Mali in April 2012, sending poorly disciplined and equipped Malian forces retreating in disarray. France launched its military intervention in its former colony on Jan. 11 when the Islamic radicals, many of whom had fought for ex-Libyan leader Moammar Gadhafi, began encroaching on the south, threatening the capital Bamako which lies deep in southern Mali, 1,200 kilometers (750 miles) from Gao.

France has said that it wants to hand over responsibility to the Malian military and other African nations who have contributed troops and has raised with the United Nations Security Council the possibility of establishing a U.N. peacekeeping operation in Mali.

Sunday's open combat and the two suicide bomb explosions have frightened many Gao residents.

Fears of suicide bombing attacks in Gao have been high since the discovery of industrial-strength explosives in the city last week. Four Malian soldiers also were killed by a land mine in the town of Gossi, raising fears the militants were planting explosives in the road.

Friday's suicide bomber had been living at a known jihadist hideout in Gao, according to local residents. A guard at the home said that it had been visited three months ago by the one-eyed terror leader Moktar Belmoktar, who claimed responsibility for the attack on the BP-operated natural gas plant in Algeria last month.

Other jihadist leaders from MUJAO also had stayed in the luxurious two-story home with a verdant courtyard, which the militants took over when they captured Gao last year, the guard said.

On Sunday, crowds of nearby residents gathered under the shade of a few trees by the site of the suicide bombing attack. It was the second time in as many days that their homes had been shaken by blasts from suicide bombers.

"I am really afraid. You hear about these kinds of things in Pakistan or Afghanistan," said Maouloud Dicko, 30, as he sat on his motorcycle. "Gao is becoming like Pakistan."

Source: http://news.yahoo.com/islamic-extremists-attack-malian-troops-gao-225124291.html

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Friday, February 8, 2013

Surgeons find better ways to treat nerve compression disorder that can sideline athletes, studies suggest

Feb. 7, 2013 ? Two new studies from Washington University School of Medicine in St. Louis suggest ways to improve surgical treatment for a debilitating condition caused by compressed nerves in the neck and shoulder.

The condition, neurogenic thoracic outlet syndrome, causes pain, numbness or tingling in the shoulder, arm or hand and is perhaps best known for affecting baseball pitchers and other elite athletes. Patients often describe pain and tension in the neck and upper back, numbness and tingling in the fingers, headaches and perceived muscle weakness in the affected limb.

Treatment begins with physical therapy and sometimes medications such as anti-inflammatory drugs and muscle relaxants. When these treatments fail to improve symptoms and there is substantial disability in the use of the affected upper extremity, surgery can help relieve pressure on the nerves, often by removing the first rib and other structures thought to be causing the compression.

One study reported that adolescents do even better after surgery than adults, but evidence suggests that this may not be due to age alone. In the second study, the researchers found that minimally invasive surgery may be just as good for select patients as the traditional, more extensive approach.

Both studies appear online in the Journal of Vascular Surgery and are important contributions to the field, according to the papers' senior author, Robert W. Thompson, MD, professor of surgery and director of the Washington University Center for Thoracic Outlet Syndrome at Barnes-Jewish Hospital.

The center treats one of the highest volumes of patients in the country, and the paper comparing treatment outcomes by age includes the largest series of adolescent patients reported in the literature to date.

"This is an important message for pediatricians who treat teenagers, especially teenage athletes," Thompson says. "These are patients who can do extremely well if identified early and treated."

The study compared outcomes of the traditional surgery in 189 patients treated from 2008 through 2010. Thirty-five of the patients were under age 21, with an average age of 17. The remaining 154 patients were over age 21, with an average age of 40.

Both groups showed substantial improvement in symptoms and function at three and six months after surgery, but the adolescent group did significantly better. In fact, a combined measure of shoulder, arm and hand function, pain and severity of symptoms was almost four times better in the adolescent group than the adult group six months after surgery. Adults also reported about four times greater use of pain medication after surgery compared to adolescents.

While much of this gap may simply be attributed to age, other differences between the two groups could be useful in identifying ways to improve outcomes for adult patients. For example, duration of pain and use of opiate pain medications before surgery were significantly higher in adults, perhaps contributing to their merely moderate improvement, compared with younger patients. Such evidence suggests that if adults were to seek treatment earlier or use less pain medication, they would perhaps do better following surgery.

"These factors may be related to age to some degree, but we need to sort that out," Thompson says. "Here we have a young group of patients that consistently does very well after surgery. If we can determine which factors contribute to their good outcomes that are independent of age, we may be able to improve the outcomes even further for our adult patients."

The second paper showed that certain patients may do just as well with a minimally invasive procedure done on an outpatient basis as those who require the traditional surgery. The traditional procedure has an average five-day hospital stay.

This study looked at 200 patients treated for neurogenic thoracic outlet syndrome from 2008 through 2011. To determine the best surgical approach for each patient, the doctor examined two locations of potential nerve compression -- the side of the neck above the collarbone and the upper chest just below the collarbone, near the shoulder.

If patients experienced pain and tenderness in both places, they were offered the traditional procedure that includes removing the first rib and scalene muscles in the neck and detaching the tendon of the pectoralis minor muscle, which connects to the top and front of the shoulder blade. Of the 200 patients, 143 underwent this procedure.

When symptoms occurred exclusively under the collarbone, patients only received detachment of the pectoralis minor tendon as a minimally invasive procedure. The remaining 57 participants in the study underwent this outpatient procedure.

To determine outcomes, the researchers compared various measures of the patients' arm and shoulder function before surgery and again three months after surgery. Both sets of patients improved significantly after surgery, and the extent of their improvement was not statistically different. At the three-month mark, about 75 percent of patients in both groups demonstrated improved function in the affected areas.

"The ideal candidate for the minimally invasive procedure would be a patient with characteristic and debilitating symptoms, no response to physical therapy and clinical exam findings that were completely localized to the pectoralis minor tendon," Thompson says. "That's the really exciting subset of patients. You might be able to have a big impact with a minor outpatient procedure. The trick is to properly identify these patients. We still have to rely primarily on the experience of the physician and old-fashioned diagnosis by physical exam -- knowing the anatomy, knowing what we're feeling and what elicits symptoms."

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Story Source:

The above story is reprinted from materials provided by Washington University in St. Louis. The original article was written by Julia Evangelou Strait.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Francis J. Caputo, Anna M. Wittenberg, Chandu Vemuri, Matthew R. Driskill, Jeanne A. Earley, Rahul Rastogi, Valerie B. Emery, Robert W. Thompson. Supraclavicular decompression for neurogenic thoracic outlet syndrome in adolescent and adult populations. Journal of Vascular Surgery, 2013; 57 (1): 149 DOI: 10.1016/j.jvs.2012.07.025
  2. Chandu Vemuri, Anna M. Wittenberg, Francis J. Caputo, Jeanne A. Earley, Matt R. Driskill, Rahul Rastogi, Valerie B. Emery, Robert W. Thompson. Early effectiveness of isolated pectoralis minor tenotomy in selected patients with neurogenic thoracic outlet syndrome. Journal of Vascular Surgery, 2013; DOI: 10.1016/j.jvs.2012.11.045

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/-3JrX6k8LOI/130207192107.htm

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Thursday, February 7, 2013

At Obama's inauguration, a Stars and Stripes made in Belgium?

BRUSSELS (Reuters) - When President Barack Obama was sworn in for his second term on January 21, it's a decent bet that one of the flags fluttering behind him on the U.S. Capitol was made in Belgium.

The Waelkens flag company, based in the small town of Oostrozebeke in Flanders, supplies around 2,000 flags a year to the United States, with clients including the Pentagon and other U.S. government departments as well as the United Nations.

But it's not just the far side of the Atlantic where the company is gaining ground - it also makes flags for NATO, national militaries, the European Union and just about every country in the world, from China to Nigeria.

"We have a lot of know-how about how we have to make flags and a big tradition of embroidery," said Benedikt Waelkens, who runs the company with his brother, David. "There aren't a lot of people in the world who can and are making handmade flags."

Benedikt said clients keep coming back because of the company's unique flag-making knowledge and its faithfulness to tradition. National and institutional flags have extremely precise guidelines about how they must be made - down to the number of stitches per centimeter and specific fabric shades.

What began in 1928 as a family business making embroidered garments for priests is now, four generations later, an international enterprise with a growing reputation.

Nearly half of Waelkens' flags are embroidered - some even by hand - setting the company apart from competitors who produce printed flags. David believes embroidery carries more symbolism and likens it to art, since a handmade flag can take four or five days to complete.

Benedikt said a large, handmade U.S. flag costs about 400 euros ($540). Waelkens has four-year contracts with the EU, NATO and the United Nations - each of which have scores of buildings and hundreds of ceremonial rooms that fly flags.

Benedikt explains the business in terms of hierarchy: the highest-profile EU or UN officials have the nicest flags in their offices - made of silk, embroidered and with fringe. But below the top, there are hundreds if not thousands of other civil servants who also have banners, albeit of lesser quality.

During the financial crisis in 2007, Waelkens moved its screen printing business to Romania, but the brothers say they want to keep most of the company in Belgium for tradition's sake.

Benedikt wouldn't give details on the privately held company's income but said 2012 was its best year. He attributes the success in part to consolidation in the industry as well as to the company's vertically integrated model - it makes, sells and markets its flags and even produces the flagpoles.

But perhaps the key to the business is its personal, family touch - some of the brothers' current employees also worked for their father and with their grandfather.

"Human capital of the company is the most important thing," said Benedickt. "Happiness of your people, you cannot buy that."

(This version of the story corrects the headline to add the question mark and clarifies the U.S. government departments in paragraph two.)

(Reporting By Teddy Nykiel; editing by Luke Baker and Matthew Tostevin)

Source: http://news.yahoo.com/obamas-inauguration-stars-stripes-made-belgium-181946720.html

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Liberty Global to buy Virgin Media for $16B

ENGLEWOOD, Colo. (AP) ? Liberty Global Inc., the cable TV operator owned by media mogul John Malone, is buying U.K.-based Virgin Media Inc. in a deal valued at $16 billion.

The cash and stock deal announced late Tuesday creates a company that will provide stiffer competition in the U.K. to satellite TV provider BSkyB, in which Malone's rival Rupert Murdoch's News Corp. owns a 40 percent stake.

Liberty Global and Virgin Media said tie-up will create a broadband communications company covering 47 million homes and with 25 million customers in 14 countries.

Liberty Global has pay-TV operations around the world and is the largest cable operator in most of its 11 European markets.

Liberty Global's CEO Mike Fries said that after the deal, about 80 percent of the company's revenue will come from five countries: the U.K., Germany, Belgium, Switzerland and the Netherlands. The two companies said they had combined revenue of $16.8 billion last year.

Virgin Media is the second-biggest pay TV company in the U.K. after BSkyB, or British Sky Broadcasting Group PLC. Virgin Group boss Richard Branson ? a multibillionaire, like Malone and Murdoch ? still holds a minority stake.

The companies said the transaction is equal to $47.87 per Virgin Media share. That's about a 24 percent premium on the closing price of Virgin Media's U.S.-traded stock on Monday.

The stock surged almost 18 percent Tuesday to close at $45.61 after the company said it was in acquisition talks with Liberty Global.

Liberty Global will remain based in Englewood, Colo., while Virgin Media will continue to operate under its namesake brand in the U.K.

Virgin Media shareholders are set to get about 36 percent of Liberty Global's outstanding shares and about 26 percent of the voting rights, the companies said.

They added that they expect about $180 million in annual costs savings once they are fully combined. They didn't say whether any of their employees will be laid off as part of the cost cutting. More details about the companies' plan could emerge during a management conference call scheduled for 8:30 a.m. EST Wednesday.

Liberty Media also said it plans to buy back about $3.5 billion worth of its shares over a two-year period after the Virgin Media deal is closed.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-05-Liberty%20Global-Virgin%20Media/id-8b4a62dad106451d81b859556ef4735b

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Wednesday, February 6, 2013

Cancer researchers reveal mechanism to halt cancer cell growth, discover potential therapy

Feb. 4, 2013 ? University of Pittsburgh Cancer Institute (UPCI) researchers have uncovered a technique to halt the growth of cancer cells, a discovery that led them to a potential new anti-cancer therapy.

When deprived of a key protein, some cancer cells are unable to properly divide, a finding described in the cover story of the February issue of the Journal of Cell Science. This research is supported in part by a grant from the National Institutes of Health.

"This is the first time anyone has explained how altering this protein at a key stage in cell reproduction can stop cancer growth," said Bennett Van Houten, Ph.D., the Richard M. Cyert Professor of Molecular Pharmacology at UPCI and senior author of the research paper. "Our hope is that this discovery will spur the development of a new type of cancer drug that targets this process and could work synergistically with existing drugs."

All cells have a network of mitochondria, which are tiny structures inside cells that are essential for energy production and metabolism. Dynamin-related protein 1 (Drp1) helps mitochondria undergo fission, a process by which they split themselves into two new mitochondria.

In breast or lung cancer cells made to be deficient in Drp1, the researchers observed a huge network of highly fused mitochondria. These cancer cells appear to have stalled during a stage in cell division called G2/M. Unable to divide into new cells, the cancer growth stops. Those cells that do try to divide literally tear their chromosomes apart, causing more stress for the cell.

The cover of the Journal of Cell Science includes a colorful image of a breast cancer cell deficient in Drp1 that is stuck during the process of separating its chromosomes into two identical sets to be divided among two new cells. Lead author Wei Qian, Ph.D., a postdoctoral fellow in Dr. Van Houten's laboratory, captured the image using a confocal microscope at Pitt's Center for Biologic Imaging run by Simon Watkins, Ph.D., a co-author of this study.

"Once we revealed this process for halting cancer cell growth by knocking out Drp1, we began looking into existing compounds that might utilize a similar mechanism," said Dr. Van Houten. "Now that we know affecting mitochondria in this manner inhibits cell growth, we could target drugs to this biological process to treat cancer."

The researchers found a compound called Mdivi-1 that makes cancer cells behave much the way they do when deficient in Drp-1. When used in combination with cisplatin, a drug already used to treat many solid cancers, rapid cell death can be induced in a wide range of cancer cells. This means that Mdivi-1 makes cisplatin work better.

Mdivi-1 is being tested in cancer cells in a laboratory setting. Those tests show that, while the compound acts as though it is depriving cancer cells of Drp1, it is actually using a different mechanism.

"To me, that's the serendipity of science, and it's really exciting," said Dr. Van Houten, who hopes eventually to move his laboratory tests on Mdivi-1 to clinical trials. "We were on the hunt for a drug that could make cancer cells deficient in Drp1 and, instead, we found a new cancer therapy that seems to work really well."

Additional co-authors include Serah Choi, Gregory A. Gibson, and Christopher J. Bakkenist, Ph.D., all of the University of Pittsburgh.

This work was funded in part by a grant with the Pennsylvania Department of Health, PA CURE. It also was supported by funding from NIH grants R01CA148644, P30CA047904, P50CA097190, and P50CA121973.

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The above story is reprinted from materials provided by University of Pittsburgh Schools of the Health Sciences.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/y4P3KhRaN3Q/130204095928.htm

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"A good place to start is with the kids"

House Majority Leader Eric Cantor (R-VA) listens to his introduction before speaking at the American Enterprise??

House Majority Leader Eric Cantor, R-Va., said on Tuesday that the children of illegal immigrants should be granted a path to citizenship, providing a clue about how the GOP-controlled House may tackle immigration reform this year.

"A good place to start is with the kids," Cantor said during his speech at the American Enterprise Institute. "One of the great founding principles of our country was that children would not be punished for the mistakes of their parents. It is time to provide an opportunity for legal residence and citizenship for those who were brought to this country as children and who know no other home."

Earlier on Tuesday, Cantor declined to endorse a bipartisan immigration reform blueprint in the Senate, which calls for a gradual path to citizenship for most of the nation's 11 million illegal immigrants. Whether to legalize most of that group is likely to be a sticking point between Democrats and Republicans as they hash out a reform plan.

Source: http://news.yahoo.com/blogs/ticket/eric-cantor-says-undocumented-children-offered-citizenship-194427232--election.html

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Sunday, February 3, 2013

Mali hails 'savior' Hollande, he says fight not over

TIMBUKTU, Mali/BAMAKO (Reuters) - Cheering, grateful Malians mobbed French President Francois Hollande on Saturday as he visited French troops fighting Islamist jihadist rebels, and he pledged France would finish the job of restoring government control in the Sahel state.

In a one-day trip to Mali accompanied by his ministers for defense, foreign affairs and development, Hollande was hailed as a liberator in the ancient northern city of Timbuktu, which French and Malian forces retook from the rebels six days ago.

He also received a rapturous reception in the capital Bamako, where he said the Islamist fighters allied to al Qaeda had suffered heavy losses in a three-week-old French intervention that he ordered last month at Mali's request.

Although the insurgents have been driven from Mali's main northern towns, Hollande cautioned that the task of France's military operation in Mali, codenamed Serval (Wildcat) and involving 3,500 soldiers on the ground, was not yet over.

"There is still a whole part of the north that remains unconquered ... There are terrorist elements concentrated in some areas of the country, others who are dispersed. There are risks of terrorism. So, we have not yet finished our mission," he told a news conference at the French ambassador's residence.

He added France would withdraw its troops from Mali once the West African country had restored sovereignty over all its national territory and a U.N.-backed African military force, which is being deployed, could take over from the French.

"We do not foresee staying indefinitely," he said, but he spelled out no specific time frame for the French mission.

Mali's interim President Dioncounda Traore thanked "our brother" Hollande for launching the French intervention. It has cost the life of only one French serviceman so far and has driven the rebels into the mountains of northeast Mali.

"Together we will hunt the terrorists down to their last hiding place," Traore said.

In Timbuktu, several thousand local residents in colorful robes and wraps sang and danced, shouting "Thank you, France" and "Papa Hollande". In Bamako, there were similar scenes, with thousands cheering Hollande and waving French flags.

"Vive Hollande, Vive la France," said one Bamako resident, Sidibe Lisa Camara. "Hollande our Savior!" read one banner.

The United States and the European Union are backing the Mali intervention as a counter strike against the threat of Islamist jihadists using the inhospitable and ungoverned Malian Sahara as a launch pad for international attacks.

They are providing training, logistical and intelligence support, but have ruled out sending their own ground troops.

TIMBUKTU TO "SHINE" AGAIN

In Timbuktu, the Saharan trading town and seat of Islamic learning that spent 10 months under rebel occupation, Hollande visited the Djingarei-ber Mosque and the Ahmed Baba Institute, a library of ancient manuscripts that was ransacked by the rebels.

Hollande said it was essential that Timbuktu, a UNESCO World Heritage site, should be properly protected so that it could "shine" as a cultural treasure for the world.

Heavily armed French soldiers in armored vehicles and Malian troops protected the French leader as he visited the mosque, which was built from mud bricks and wood in 1325.

"We have got our old lives back," said Khalifa Cisse, the muezzin or crier who calls the faithful to prayer at the mosque.

Hollande has repeated that the French operation, where the ground forces are backed by warplanes, helicopters and armored vehicles, aims to make way eventually for the larger multi-national African force, which is still being put in place.

Drawn mostly from Mali's West African neighbors, this force is expected to number more than 8,000. But its deployment has been badly hampered by shortages of kit and airlift capacity and questions about who will fund the estimated $1 billion cost.

France's role in Mali has raised fears of reprisal attacks by Islamist radicals against French and other Westerners.

A Frenchman was among four people killed in Senegal's southern Casamance region on Friday when suspected separatists clashed with troops, but the incident did not appear to be linked to Mali.

UNVEILED WOMEN DANCE WITH JOY

The international community has greeted the liberation of Timbuktu with relief. It is a center of Islamic scholarship in the tolerant Sufi tradition, but the radical Islamist occupiers smashed ancient Sufi mausoleums, calling them idolatrous.

The rebels also destroyed up to 2,000 of some 300,000 priceless ancient manuscripts held in the city. Experts say the bulk of the texts are secure and safe, however.

Timbuktu residents rejoiced at being freed from the severe version of sharia (Islamic law) imposed by the rebels, who had forced women to go veiled and inflicted beatings and amputations. Hollande said Mali's courts and the International Criminal Court should try those responsible for war crimes.

"These so-called Islamists did nothing but evil to us, they beat people, they cut off limbs," said Lala Toure, a woman who went unveiled and wore a short-sleeved white T-shirt with the printed words "Thank you France for your help".

Cisse, the muezzin, said the rebels, grouped in a loose alliance that includes al Qaeda's North African wing AQIM, had tried to impose an unfamiliar radical form of Islam on Mali.

French air strikes have forced the rebel fighters to retreat into the remote Adrar des Ifoghas mountains near the Algerian border. Hollande said this was where the rebels were holding seven French hostages previously seized in the Sahel.

He called on the jihadists to release the hostages and said everything was being done to obtain their freedom.

The next stage of the fight against the rebels, in a harsh Saharan battleground, could test the French and Malian forces and their African and other allies.

(Additional reporting by Elena Berton in Paris; Writing by Pascal Fletcher; Editing by Stephen Powell)

Source: http://news.yahoo.com/french-president-visits-mali-support-french-troops-084423526.html

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